G. L. Smith

A machine learning approach to predict drug-induced autoimmunity using transcriptional data.

This paper uses an ensemble machine learning approach to predict drug-induced autoimmunity from transcriptional data, identifying dysregulated cell cycling as a potential mechanism.

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.

Transcriptional reprogramming of natural killer cells by vaccinia virus shows both distinct and conserved features with mCMV

This study examines how vaccinia virus reprograms NK cell transcription and compares it to MCMV, finding both conserved and distinct features across species.

zDHHC5 expression is increased in cardiac hypertrophy and reduced in heart failure but this does not correlate with changes in substrate palmitoylation

This study examines zDHHC5 expression and palmitoylation changes in cardiac diseases, finding increased zDHHC5 in hypertrophy and decreased in failure, with no correlation to substrate palmitoylation changes.

Cardiac myosin binding protein-C palmitoylation is associated with increased myofilament affinity, reduced myofilament Ca2+ sensitivity and is increased in ischaemic heart failure.

This study identifies palmitoylation of cMyBP-C in cardiac myofilaments, showing it reduces Ca2+ sensitivity and is altered in heart failure.

The crystal structure of vaccinia virus protein E2 and perspectives on the prediction of novel viral protein folds

This paper reports the crystal structure of vaccinia virus protein E2 and demonstrates that AlphaFold2 accurately predicts its structure despite its novelty and lack of sequence homology.

Selective modulation of cell surface proteins during vaccinia infection: implications for immune evasion strategies

This study quantifies PM protein modulation during vaccinia infection, identifying downregulated immune ligands and upregulated decoy receptors, revealing immune evasion strategies.

Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and enhance immunity

This paper shows that smallpox vaccination with VACV increases skin commensal bacteria, which promote tissue damage but also enhance immunity and antibody responses.

A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses

This study identifies a poxvirus protein that inhibits STAT1 signaling by binding its SH2 domain, revealing a conserved mechanism across poxviruses and paramyxoviruses.

Viral mimicry of p65/RelA transactivation domain to inhibit NF-κB activation

This paper identifies a viral protein that mimics a host protein to inhibit NF-κB activation, revealing a mechanism of viral immune evasion.

The actin nucleator Spir-1 is a virus restriction factor that promotes IRF3 activation

This paper identifies Spir-1 as a virus restriction factor that enhances IRF3 activation in response to RNA viruses and is targeted by the viral protein K7 to suppress antiviral responses.

Novel role for ESCRT-III component CHMP4C in the integrity of the endocytic network utilized for herpes simplex virus envelopment

The paper identifies CHMP4C as a critical fission factor required for HSV1 envelopment by maintaining the integrity of the recycling endocytic network.

DDX50 is a viral restriction factor thay enhances TRIF-dependent IRF3 activation

This paper identifies DDX50 as a viral restriction factor that enhances TRIF-dependent IRF3 activation, thereby restricting viral replication and dissemination.

Golgi anti-apoptotic proteins are evolutionarily conserved ion channels that regulate cell death in plants

This study identifies plant GAAPs as Golgi-localized ion channels that regulate cell death by modulating ionic homeostasis, showing functional conservation with human and viral GAAPs.

Enhanced efficacy of vaccination with vaccinia virus in old versus young mice

This study shows that vaccinia virus vaccination induces comparable immune responses and protection in old and young mice, suggesting its potential for improving vaccine efficacy in the elderly.

GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes

This study shows that human iPSC-derived cardiomyocytes lack GLUT4 expression and insulin-stimulated glucose uptake, limiting their utility in modeling cardiac metabolic disorders.

Molecular basis of Cul3 ubiquitin ligase subversion by vaccinia virus protein A55

This study identifies the molecular mechanism by which vaccinia virus protein A55 subverts the Cul3 ubiquitin ligase, showing high-affinity binding and structural similarity to cellular BTB-Kelch proteins.

Versatile open software to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo

MUSCLEMOTION quantifies cardiac contraction in vitro and in vivo, providing reliable pharmacological and disease phenotype data across multiple models.