G. S. Baillie

MYPT1 is a non-canonical AKAP that tethers PKA to the MLCP signaling node

This study identifies MYPT1 as a non-canonical AKAP that directly interacts with PKA-R variants to tether PKA to the MLCP signaling node.

Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor

This study identifies the structural basis of MITF's interaction with CBP/p300 TAZ domains, revealing an acidic motif essential for transcriptional activity and showing that E1A can inhibit this interaction.

zDHHC5 expression is increased in cardiac hypertrophy and reduced in heart failure but this does not correlate with changes in substrate palmitoylation

This study examines zDHHC5 expression and palmitoylation changes in cardiac diseases, finding increased zDHHC5 in hypertrophy and decreased in failure, with no correlation to substrate palmitoylation changes.

Cardiac myosin binding protein-C palmitoylation is associated with increased myofilament affinity, reduced myofilament Ca2+ sensitivity and is increased in ischaemic heart failure.

This study identifies palmitoylation of cMyBP-C in cardiac myofilaments, showing it reduces Ca2+ sensitivity and is altered in heart failure.

Reduced PDE4D7 expression in prostate cancer correlates with down-regulation of genomic elements within the upstream PDE4D coding region on chromosome 5

The paper identifies PDE4D7 expression reduction in prostate cancer and links it to genomic elements in the upstream PDE4D coding region, suggesting potential biomarkers and mechanistic roles in cancer progression.

Phosphodiesterase Type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins.

The paper shows Popeye domain-containing proteins form complexes with PDE4 phosphodiesterases in cardiac myocytes, restricting cAMP signaling and maintaining action potential duration.