Author

R. M. Crean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

C. R. Pudney· 2 shared M. W. van der Kamp· 2 shared A. J. Mulholland· 1 shared A. K. Warrender· 1 shared A. Steyn-Ross· 1 shared C. J. Hamill· 1 shared D. K. Cole· 1 shared E. J. Prentice· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiochemistry

C. R. Pudney

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 6, 2023

Cooperative conformational transitions and the temperature dependence of enzyme catalysis

E. J. Walker, C. J. Hamill, R. M. Crean…·V. L. Arcus

This study investigates the temperature dependence of enzyme catalysis by analyzing MalL and its mutants, showing cooperative conformational transitions and introducing models to explain non-Arrhenius behavior.

DOI 10.1101/2023.07.06.548038

structural biologystatistical model

𝕏 PostBluesky

BiophysicsbioRxivJun 21, 2021

Reliable in silico ranking of engineered therapeutic TCR binding affinities with MMPBSA and MMGBSA.

M. W. Van der Kamp, R. M. Crean, D. K. Cole, C. R. Pudney

This study develops protocols for reliable in silico ranking of TCR binding affinities using MMPBSA and MMGBSA methods, showing that short MD simulations can accurately evaluate TCR variants.

DOI 10.1021/acs.jcim.1c00765

protein structuredeep learning

𝕏 PostBluesky