Author

E. J. Walker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Organism:E. coli· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Q. Bettinger· 2 shared J. R. Hryhorenko· 2 shared K. A. Welle· 2 shared S. Ghaemmaghami· 2 shared A. J. Mulholland· 1 shared A. K. Warrender· 1 shared A. M. M. Vargas· 1 shared A. Steyn-Ross· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

J. Q. Bettinger

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Author profile →

3 papers

Recent·Most cited

Cooperative conformational transitions and the temperature dependence of enzyme catalysis

E. J. Walker, C. J. Hamill, R. M. Crean, M. S. Connolly, A. K. Warrender, K. L. Kraakman, E. J. Prentice, A. Steyn-Ross, M. Steyn-Ross, C. R. Pudney, M. W. van der Kamp, L. A. Schipper, A. J. Mulholland, V. L. Arcus

This study investigates the temperature dependence of enzyme catalysis by analyzing MalL and its mutants, showing cooperative conformational transitions and introducing models to explain non-Arrhenius behavior.

bioRxiv · Jul 6, 2023 · PreprintBiochemistry

Protein folding stabilities are a major determinant of oxidation rates for buried methionine residues

E. J. Walker, J. Q. Bettinger, K. A. Welle, J. R. Hryhorenko, A. M. M. Vargas, M. R. O'Connell, S. Ghaemmaghami

The paper shows that oxidation rates of buried methionines correlate with protein folding stability, using E. coli and T. thermophilus proteomes to demonstrate this relationship.

bioRxiv · Dec 20, 2021Biochemistry

Global analysis of methionine oxidation provides a census of folding stabilities for the human proteome

E. J. Walker, J. Q. Bettinger, K. A. Welle, J. R. Hryhorenko, S. Ghaemmaghami

The paper quantifies protein folding stabilities in human cell extracts using methionine oxidation rates, identifying stable ontological subsets and showing stability impacts oxidation and TMAO effects.

bioRxiv · Jan 10, 2019Biochemistry