Author

D. K. Cole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Greenshields-Watson· 1 shared A. L. Parker· 1 shared A. T. Baker· 1 shared A. Vantellini· 1 shared C. R. Pudney· 1 shared F. Amicarella· 1 shared H. Uusi-Kerttula· 1 shared I. B. Robertson· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Greenshields-Watson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tuning the potency and therapeutic window of ImmTAC molecules by affinity modulation

I. B. Robertson, R. M. Mulvaney, N. Dieckmann, A. Vantellini, M. Canestraro, F. Amicarella, R. O'Dwyer, D. K. Cole, S. Harper, O. Dushek, P. Kirk

This paper investigates how altering affinity for target and CD3 affects the potency and specificity of ImmTAC molecules, finding that optimal activation occurs with strong TCR affinity and intermediate anti-CD3 affinity.

bioRxiv · Nov 3, 2022 · PreprintImmunology

Reliable in silico ranking of engineered therapeutic TCR binding affinities with MMPBSA and MMGBSA.

M. W. Van der Kamp, R. M. Crean, D. K. Cole, C. R. Pudney

This study develops protocols for reliable in silico ranking of TCR binding affinities using MMPBSA and MMGBSA methods, showing that short MD simulations can accurately evaluate TCR variants.

bioRxiv · Jun 21, 2021Biophysics

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions.

A. T. Baker, A. Greenshields-Watson, L. Coughlan, J. A. Davies, H. Uusi-Kerttula, D. K. Cole, P. J. Rizkallah, A. L. Parker

The paper investigates receptor interactions of HAdV-D26/48 fiber-knob protein, finding low affinity for CAR and no evidence of interaction with CD46 or Desmoglein 2.

bioRxiv · Jan 11, 2019Microbiology