Author

R. M. Knutila

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1

Frequent Co-Authors

I. Y. Kuo· 2 shared A. B. Chapman· 1 shared B. Elliott· 1 shared D. Y. Barefield· 1 shared E. DiNello· 1 shared G. E. Fritzmann· 1 shared K. M. Marquez-Nogueras· 1 shared K. M. Marquez-Nogueraz· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPhysiology

I. Y. Kuo

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2 papers

Recent·Most cited

Cardiac Localized Polycystin-2 plays a Functional Role in Natriuretic Peptide Production and its Absence Contributes to Hypertension

B. Elliott, K. M. Marquez-Nogueraz, P. Thuo, E. DiNello, R. M. Knutila, G. E. Fritzmann, M. Willis, A. B. Chapman, Q. Cao, D. Y. Barefield, I. Y. Kuo

This study shows that cardiac polycystin-2 is involved in natriuretic peptide production, and its absence leads to hypertension in ADPKD mice.

bioRxiv · Jan 2, 2024Physiology

TRiPPing the sensors: The osmosensing pathway of Polycystin 2

K. M. Marquez-Nogueras, R. M. Knutila, V. Vuchkovska, I. Y. Kuo

This study identifies osmolarity as a physiological activator of ER-localized PC2 and shows that MAP4-dependent microtubule stabilization is required for PC2's role in osmosensing and urine concentration.

bioRxiv · May 9, 2023 · PreprintPhysiology