Natural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation
E. A. van Erp, A. J. Lakerveld, E. de Graaf, M. D. Larsen, R. M. Schepp, A. L. Hipgrave Ederveen, I. M. L. Ahout, C. A. M. de Haan, M. Wuhrer, W. Luytjes, G. Ferwerda, G. Vidarsson, P. B. van Kasteren
The paper examines how RSV-specific antibodies from infants with severe respiratory infections activate NK cells and links this to Fc-glycosylation, finding reduced activation in infected infants.
bioRxiv · Nov 4, 2019Immunology