R. M. Sears

Mechanisms by which barrier-to-autointegration factor regulates dynamics of nucleocytoplasmic leakage and membrane repair following nuclear envelope rupture

This study identifies BAF's role in reducing nucleocytoplasmic leakage and facilitating membrane repair after nuclear envelope rupture through phosphoregulation of DNA binding.

Mechanisms of A-type lamin targeting to nuclear ruptures are disrupted in LMNA- and BANF1-associated progerias

This study identifies how A-type lamins are recruited to nuclear ruptures and shows how progeria-linked mutations in LMNA and BANF1 disrupt this process.

Reducing shock imminence eliminates poor avoidance in rats

The paper shows that reducing shock imminence in rats improves avoidance behavior and eliminates poor avoidance in all subjects.