Author

K. J. Roux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

K. L. Scott· 2 shared R. M. Sears· 2 shared A. Katiyar· 1 shared B. F. Tan· 1 shared C. A. Reinhart-King· 1 shared C. Aitken· 1 shared C. Espejo-Serrano· 1 shared C. Gontan· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

K. L. Scott

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4 papers

Recent·Most cited

Mechanisms by which barrier-to-autointegration factor regulates dynamics of nucleocytoplasmic leakage and membrane repair following nuclear envelope rupture

C. T. Halfmann, K. L. Scott, R. M. Sears, K. J. Roux

This study identifies BAF's role in reducing nucleocytoplasmic leakage and facilitating membrane repair after nuclear envelope rupture through phosphoregulation of DNA binding.

bioRxiv · Dec 21, 2023 · PreprintCell Biology

Specific genomic targeting of the RNF12/RLIM E3 ubiquitin ligase selectively programmes developmental transcription

C. Espejo-Serrano, C. Aitken, B. F. Tan, D. G. May, R. J. Chrisopulos, K. J. Roux, S. G. Mackintosh, J. Gribnau, F. Bustos, C. Gontan, G. M. Findlay

This study identifies how RNF12/RLIM E3 ubiquitin ligase targets specific genomic regions to regulate gene expression through chromatin interactions and autoinhibitory mechanisms.

bioRxiv · Jun 14, 2023 · PreprintCell Biology

The nucleus bypasses obstacles by deforming like a drop with surface tension mediated by lamin A/C

A. Katiyar, J. Zhang, J. D. Antani, Y. Yu, K. L. Scott, P. P. Lele, C. A. Reinhart-King, N. J. Sniadecki, K. J. Roux, R. B. Dickinson, T. P. Lele

The paper shows lamin A/C enables nuclear deformation through fibrous environments by acting like surface tension, allowing nuclei to bypass obstacles without rupturing.

bioRxiv · Mar 10, 2022 · PreprintCell Biology

Mechanisms of A-type lamin targeting to nuclear ruptures are disrupted in LMNA- and BANF1-associated progerias

R. M. Sears, K. J. Roux

This study identifies how A-type lamins are recruited to nuclear ruptures and shows how progeria-linked mutations in LMNA and BANF1 disrupt this process.

bioRxiv · Jan 14, 2022Cell Biology