R. M. Voorhees

The paper studies the biogenesis of ER membrane proteins, identifying the EMC and BOS complex as key players and proposing a model for coordinated insertion.

The paper identifies distinct chaperone machinery for targeting mitochondrial outer membrane -helical proteins based on their topology using CRISPRi screens and biochemical analysis.

This paper introduces a method for rapidly purifying native human protein complexes using nanobodies and lentiviral transduction, achieving high purity and yield in ~8 days.

The paper shows the EMC uses a selectivity filter to prevent mitochondrial tail-anchored proteins from mislocalizing to the ER.

The paper identifies MTCH2 as an insertase required for mitochondrial TA protein insertion and shows its role in controlling TA localization and apoptosis sensitivity.

The paper shows that circadian protein rhythms are compensated by ion transport to maintain osmotic balance and cellular function in mammalian cells and cardiomyocytes.