T. Pleiner

Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins

The paper studies the biogenesis of ER membrane proteins, identifying the EMC and BOS complex as key players and proposing a model for coordinated insertion.

Nucleoporin-binding nanobodies that either track or inhibit nuclear pore complex assembly

The paper introduces nanobodies that track or inhibit nuclear pore complex (NPC) assembly by targeting Nups and solving challenges in NPC detection and assembly inhibition.

A nanobody-based strategy for rapid and scalable purification of native human protein complexes

This paper introduces a method for rapidly purifying native human protein complexes using nanobodies and lentiviral transduction, achieving high purity and yield in ~8 days.

A selectivity filter in the EMC limits protein mislocalization to the ER

The paper shows the EMC uses a selectivity filter to prevent mitochondrial tail-anchored proteins from mislocalizing to the ER.

A toolbox of anti-mouse and rabbit IgG secondary nanobodies

This paper introduces sustainable nanobodies against mouse and rabbit IgG as alternatives to traditional animal-derived secondary antibodies, demonstrating their utility in various imaging and detection applications.