Profiling the in vitro and in vivo activity of streptothricin-F against carbapenem-resistant Enterobacterales: a historic scaffold with a novel mechanism of action
K. P. Smith, Y.-S. Kang, A. B. Green, M. G. Dowgiallo, B. C. Miller, L. Chiaraviglio, K. A. Truelson, K. E. Zulauf, S. Rodriguez, R. Manetsch, J. E. Kirby
This paper evaluates the in vitro and in vivo activity of streptothricin-F against carbapenem-resistant Enterobacterales, identifying its potent activity and novel mechanism of action involving 16S rRNA helix 34.
bioRxiv · Jun 14, 2021 · PreprintMicrobiology