EZH2 mutations in follicular lymphoma distort H3K27me3 profiles and alter transcriptional responses to PRC2 inhibition
P. Romero, L. Richart, S. Aflaki, M. Burton, A. Michaud, J. Masliah-Planchon, F. Kuhnoswki, C. Meaudre, A. Luscan, A. Hamza, P. Legoix, A. Vincent-Salomon, M. Wassef, D. Holoch, R. Margueron
This study shows that EZH2 mutations in follicular lymphoma alter H3K27 methylation and transcriptional responses to PRC2 inhibition, with clinical implications for patient stratification.
bioRxiv · Jan 2, 2023Cancer Biology