Covalent macrocyclic proteasome inhibitors mitigate resistance in Plasmodium falciparum
J. M. Bennett, K. E. Ward, R. Muir, S. Kabeche, E. Yoo, T. Yeo, G. Lam, H. Zhang, J. Almaliti, G. Berger, F. F. Faucher, G. Lin, W. H. Gerwick, E. Yeh, D. A. Fidock, M. Bogyo
This paper develops covalent macrocyclic proteasome inhibitors for Plasmodium falciparum that show reduced resistance compared to reversible inhibitors.
bioRxiv · Jul 3, 2023 · PreprintMicrobiology