Author

W. H. Gerwick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. Almaliti· 3 shared A. J. O'Donoghue· 2 shared E. Boura· 2 shared E. Glukhov· 2 shared P. Fajtova· 2 shared A. Edlund· 1 shared A. Guild· 1 shared A. K. Ecker· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

J. Almaliti

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Light-gated Integrator for Highlighting Kinase Activity in Living Cells

W. Lin, A. Phatarphekar, Y. Zhong, L. Liu, H.-B. Kwon, W. H. Gerwick, Y. Wang, S. Mehta, J. Zhang

This paper introduces KINACT, a light-gated tool that converts kinase activity into permanent fluorescent marks for analyzing kinase dynamics and signaling mechanisms.

bioRxiv · Mar 18, 2024Bioengineering

Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from the Marine Cyanobacterium Moorena producens JHB Discovered via Co-culture with Candida albicans

T.-E. Ngo, A. K. Ecker, A. Guild, A. Remmel, P. B. Boudreau, K. L. Alexander, C. B. Naman, E. Glukhov, N. E. Avalon, V. V. Shende, L. Gerwick, W. H. Gerwick

This paper identifies hectoramide B, a new linear depsipeptide from Moorena producens JHB, through co-culture with Candida albicans and genome-based biosynthesis analysis.

bioRxiv · Jul 6, 2023 · PreprintBiochemistry

Covalent macrocyclic proteasome inhibitors mitigate resistance in Plasmodium falciparum

J. M. Bennett, K. E. Ward, R. Muir, S. Kabeche, E. Yoo, T. Yeo, G. Lam, H. Zhang, J. Almaliti, G. Berger, F. F. Faucher, G. Lin, W. H. Gerwick, E. Yeh, D. A. Fidock, M. Bogyo

This paper develops covalent macrocyclic proteasome inhibitors for Plasmodium falciparum that show reduced resistance compared to reversible inhibitors.

bioRxiv · Jul 3, 2023 · PreprintMicrobiology

Development of subunit selective substrates for Trichomonas vaginalis proteasome

P. Fajtova, B. Hurysz, Y. Miyamoto, M. Serafim, Z. Jiang, D. F. Trujillo, L. J. Liu, U. Somani, J. Almaliti, S. Myers, C. Caffrey, W. H. Gerwick, C. J. Kirk, E. Boura, L. Eckmann, A. J. O'Donoghue

The paper develops three subunit-specific fluorogenic substrates for the T. vaginalis proteasome and identifies effective inhibitor targets.

bioRxiv · Apr 5, 2023 · PreprintBiochemistry

Development of Highly Selective Epoxyketone-based Plasmodium Proteasome Inhibitors with Negligible Cytotoxicity

J. Almaliti, P. Fajtova, J. Calla, G. M. LaMonte, M. Feng, F. Rocamora, S. Ottilie, E. Glukhov, E. Boura, R. T. Suhandynata, J. D. Momper, M. K. Gilson, E. A. Winzeler, W. H. Gerwick, A. J. O'Donoghue

This study develops highly selective epoxyketone-based proteasome inhibitors effective against Plasmodium falciparum with low cytotoxicity to human cells.

bioRxiv · Aug 6, 2022 · PreprintBiochemistry

Commensal oral Rothia mucilaginosa produces enterobactin - a metal chelating siderophore

C. Uranga, P. Arroyo, B. M. Duggan, W. H. Gerwick, A. Edlund

This study identifies Rothia mucilaginosa as a commensal oral bacterium producing enterobactin, a siderophore that affects the growth of pathogenic bacteria and may influence oral health.

mSystems · Apr 28, 2020Peer-reviewedMicrobiology