Author

J. Almaliti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 1 Organism:mouse· 1 Organism:plant (other)· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

E. Boura· 3 shared P. Fajtova· 3 shared W. H. Gerwick· 3 shared A. J. O'Donoghue· 2 shared B. Hurysz· 2 shared L. Eckmann· 2 shared Y. Miyamoto· 2 shared A. O Donoghue· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

E. Boura

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

J. Silhan, P. Fajtova, J. Bartosova, B. Hurysz, J. Almaliti, Y. Miyamoto, L. Eckmann, W. Gerwick, A. O Donoghue, E. Boura

This study determines the cryo-EM structures of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors, revealing their binding modes and explaining inhibitor specificity.

bioRxiv · Aug 17, 2023 · PreprintBiophysics

Covalent macrocyclic proteasome inhibitors mitigate resistance in Plasmodium falciparum

J. M. Bennett, K. E. Ward, R. Muir, S. Kabeche, E. Yoo, T. Yeo, G. Lam, H. Zhang, J. Almaliti, G. Berger, F. F. Faucher, G. Lin, W. H. Gerwick, E. Yeh, D. A. Fidock, M. Bogyo

This paper develops covalent macrocyclic proteasome inhibitors for Plasmodium falciparum that show reduced resistance compared to reversible inhibitors.

bioRxiv · Jul 3, 2023 · PreprintMicrobiology

Development of subunit selective substrates for Trichomonas vaginalis proteasome

P. Fajtova, B. Hurysz, Y. Miyamoto, M. Serafim, Z. Jiang, D. F. Trujillo, L. J. Liu, U. Somani, J. Almaliti, S. Myers, C. Caffrey, W. H. Gerwick, C. J. Kirk, E. Boura, L. Eckmann, A. J. O'Donoghue

The paper develops three subunit-specific fluorogenic substrates for the T. vaginalis proteasome and identifies effective inhibitor targets.

bioRxiv · Apr 5, 2023 · PreprintBiochemistry

Development of Highly Selective Epoxyketone-based Plasmodium Proteasome Inhibitors with Negligible Cytotoxicity

J. Almaliti, P. Fajtova, J. Calla, G. M. LaMonte, M. Feng, F. Rocamora, S. Ottilie, E. Glukhov, E. Boura, R. T. Suhandynata, J. D. Momper, M. K. Gilson, E. A. Winzeler, W. H. Gerwick, A. J. O'Donoghue

This study develops highly selective epoxyketone-based proteasome inhibitors effective against Plasmodium falciparum with low cytotoxicity to human cells.

bioRxiv · Aug 6, 2022 · PreprintBiochemistry