Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo
Q. Wang, Y. F. Guan, S. E. Hancock, K. Wahi, M. van Geldermalsen, B. K. Zhang, A. Pang, R. Nagarajah, B. Mak, L. G. Horvath, N. Turner, J. Holst
This study shows that inhibiting GMPS reduces glutamine metabolism and prostate cancer growth in vitro and in vivo.
bioRxiv · Sep 7, 2020Cancer Biology