Author

J. Holst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Pang· 2 shared K. Wahi· 2 shared L.-E. Quek· 2 shared Q. Wang· 2 shared Y. F. Guan· 2 shared A. J. Hoy· 1 shared B. K. Zhang· 1 shared B. Mak· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

A. Pang

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3 papers

Recent·Most cited

Macropinocytosis mediates resistance to loss of glutamine transport in triple-negative breast cancer

K. Wahi, N. Freidman, Q. Wang, M. Devadason, L.-E. Quek, A. Pang, L. Lloyd, M. Larance, F. Zanini, K. Harvey, S. O'Toole, Y. F. Guan, J. Holst

The paper shows that TNBC cells compensate for loss of ASCT2 glutamine uptake by increasing macropinocytosis, suggesting resistance to targeting glutamine transport alone.

bioRxiv · Feb 21, 2024Cancer Biology

Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo

Q. Wang, Y. F. Guan, S. E. Hancock, K. Wahi, M. van Geldermalsen, B. K. Zhang, A. Pang, R. Nagarajah, B. Mak, L. G. Horvath, N. Turner, J. Holst

This study shows that inhibiting GMPS reduces glutamine metabolism and prostate cancer growth in vitro and in vivo.

bioRxiv · Sep 7, 2020Cancer Biology

A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

J. L. Gillis, J. A. Hinneh, N. K. Ryan, S. Irani, M. Moldovan, R. K. Shrestha, L.-E. Quek, A. J. Hoy, J. Holst, M. M. Centenera, I. G. Mills, D. J. Lynn, L. A. Selth, L. M. Butler

This study identifies a feedback loop between the androgen receptor and 6PGD that drives prostate cancer growth and shows that targeting both improves therapeutic efficacy.

bioRxiv · Sep 2, 2020Cancer Biology