Author

L. G. Horvath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:metabolomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Y. Mah· 2 shared D. J. Lynn· 2 shared J. Dehairs· 2 shared J. V. Swinnen· 2 shared L. A. Selth· 2 shared L. M. Butler· 2 shared M. M. Centenera· 2 shared M. Moldovan· 2 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

C. Y. Mah

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Author profile →

4 papers

Recent·Most cited

Lipidomic profiling of clinical prostate cancer reveals targetable alterations in lipid composition

L. M. Butler, C. Y. Mah, J. Machiels, A. D. Vincent, S. Irani, S. Mutuku, X. Spotbeen, M. Bagadi, D. Waltregny, M. Moldovan, J. Dehairs, F. Vanderhoydonc, K. Bloch, R. Das, J. Stahl, , J. V. Swinnen

The paper profiles lipidomes in prostate cancer tissues and identifies targetable lipid alterations linked to AR signaling and therapeutic response.

bioRxiv · Oct 27, 2020Cancer Biology

Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo

Q. Wang, Y. F. Guan, S. E. Hancock, K. Wahi, M. van Geldermalsen, B. K. Zhang, A. Pang, R. Nagarajah, B. Mak, L. G. Horvath, N. Turner, J. Holst

This study shows that inhibiting GMPS reduces glutamine metabolism and prostate cancer growth in vitro and in vivo.

bioRxiv · Sep 7, 2020Cancer Biology

DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Z. D. Nassar, C. Y. Mah, J. Dehairs, I. J. G. Burvenich, S. Irani, M. M. Centenera, R. K. Shrestha, M. Moldovan, A. S. Don, A. M. Scott, L. G. Horvath, D. J. Lynn, L. A. Selth, A. J. Hoy, J. V. Swinnen, L. M. Butler

This study identifies DECR1 as an androgen-repressed gene that promotes prostate cancer cell survival by facilitating PUFA oxidation and preventing ferroptosis.

bioRxiv · Dec 6, 2019Cancer Biology

MicroRNAs as potential therapeutics to enhance chemosensitivity in advancedprostate cancer

H.-M. Lin, I. Nikolic, J. Yang, L. Castillo, N. Deng, C.-L. Chan, N. K. Yeung, E. Dodson, B. Elsworth, C. Spielman, B. Lee, Z. Boyer, K. Simpson, R. J. Daly, L. G. Horvath, A. Swarbrick

This study identifies microRNA mimics that enhance taxane-induced apoptosis in CRPC cell lines, suggesting potential therapeutic use to improve chemosensitivity.

bioRxiv · Feb 28, 2018Cancer Biology