Cancer BiologybioRxivPreprint
Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression
H. E. V. Gamage, S. H. Shahoei, S. T. Albright…·E. R. Nelson
This paper shows that NR0B2 in myeloid cells reduces Treg expansion and tumor growth by modulating the NLRP3 inflammasome, with small molecule agonists improving ICB efficacy in breast cancer.
DOI 10.1101/2023.08.14.553229