Author

E. R. Nelson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:clinical cohort / trial· 1 Organism:human· 1

Frequent Co-Authors

A. Das Gupta· 2 shared A. T. Nelczyk· 2 shared H. E. V. Gamage· 2 shared L. Ma· 2 shared N. Krawczynska· 2 shared A. Douangamath· 1 shared A. J. Smith· 1 shared A. Rose· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

A. Das Gupta

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Author profile →

4 papers

Recent·Most cited

Cholesterol Metabolite 27-Hydroxycholesterol Enhances the Secretion of Cancer Promoting Extracellular Vesicles by a Mitochondrial ROS-Induced Impairment of Lysosomal Function

A. Das Gupta, J. Park, J. E. Sorrells, H. Kim, N. Krawczynska, H. E. V. Gamage, A. T. Nelczyk, S. A. Boppart, M. D. Boppart, E. R. Nelson

This study shows that 27-hydroxycholesterol increases EV secretion by impairing lysosomal function through mitochondrial ROS, and antioxidant treatment reverses this effect.

bioRxiv · May 1, 2024 · PreprintCell Biology

Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression

H. E. V. Gamage, S. H. Shahoei, S. T. Albright, Y. Wang, A. J. Smith, R. Farmer, E. C. Fink, E. Jacquin, E. Weisser, R. O. Bautista, M. A. Henn, C. P. Schane, A. T. Nelczyk, L. Ma, A. Das Gupta, , E. R. Nelson

This paper shows that NR0B2 in myeloid cells reduces Treg expansion and tumor growth by modulating the NLRP3 inflammasome, with small molecule agonists improving ICB efficacy in breast cancer.

bioRxiv · Aug 14, 2023 · PreprintCancer Biology

Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B

T. S. Mehlman, J. T. Biel, S. M. Azeem, E. R. Nelson, S. Hossain, L. E. Dunnett, N. G. Paterson, A. Douangamath, R. Talon, D. Axford, H. Orins, F. von Delft, D. A. Keedy

This study compares cryo and room-temperature crystallography of PTP1B with small-molecule fragments, showing RT reveals different binding modes and conformational changes.

bioRxiv · Nov 2, 2022Biophysics

Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

S. A. Hutchinson, A. Websdale, P. Lianto, G. Cioccoloni, H. Roberg-Larsen, B. Kim, A. Rose, C. Soteriou, L. M. Wastall, B. Williams, M. Henn, J. J. Chen, L. Ma, J. B. Moore, E. R. Nelson, , J. L. Thorne

This study identifies LXRalpha as a driver of chemoresistance in TNBC through its regulation of P-glycoprotein, linking cholesterol metabolism to chemotherapy failure.

bioRxiv · Aug 4, 2020Cancer Biology