CBL-C E3 ubiquitin ligase acts as a host defense to mediate ubiquitin-proteasomal degradation of enteropathogenic Escherichia coli Tir protein
J. Ryu, R. Otsubo, H. Ashida, T. Iida, A. Abe, C. Sasakawa, H. Mimuro
The paper shows that CBL-C ubiquitin ligase targets Tir protein for proteasomal degradation, reducing EPEC colonization.
bioRxiv · Mar 8, 2021 · PreprintMicrobiology