Author

K. Kiga

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:bacteria (other)· 4 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. H. Azam· 7 shared S. Ojima· 5 shared K. Watashi· 4 shared Y. Takahashi· 4 shared A. Tamura· 3 shared K. Kondo· 3 shared L. Cui· 3 shared T. Nakamura· 3 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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7 shared papersMicrobiology

A. H. Azam

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Author profile →

8 papers

Recent·Most cited

Systematic Discovery of Phage Genes that Inactivate Bacterial Immune Systems

S. Ojima, A. H. Azam, K. Kondo, W. Nie, S. Wang, K. Chihara, A. Tamura, W. Yamashita, T. Nakamura, Y. Sugawara, M. Sugai, B. Zhu, Y. Takahashi, K. Watashi, K. Kiga

This study identifies phage genes that inactivate bacterial immune systems by testing gene deletions in a phage library against bacterial defense systems.

bioRxiv · Apr 14, 2024 · PreprintMicrobiology

Viruses encode tRNA and anti-retron to evade bacterial immunity

A. H. Azam, K. Chihara, K. Kondo, T. Nakamura, S. Ojima, A. Tamura, W. Yamashita, L. Cui, Y. Takahashi, K. Watashi, K. Kiga

This study identifies two viral strategies to evade bacterial retrons: supplying tRNATyr to counteract retron 78 and using Rad to degrade retron noncoding RNA precursors.

bioRxiv · Mar 15, 2023 · PreprintMicrobiology

Selective bacteriophages reduce the emergence of resistant bacteria in the bacteriophage-antibiotic combination therapy

A. H. Azam, K. Sato, K. Miyanaga, T. Nakamura, S. Ojima, K. Kondo, A. Tamura, W. Yamashita, Y. Tanji, K. Kiga

This study shows that selecting specific bacteriophages in combination with antibiotics can reduce the emergence of resistant bacteria, using Escherichia coli O157:H7 as a model.

bioRxiv · Jan 22, 2023Microbiology

Identification of inosine monophosphate dehydrogenase as a potential target for anti-monkeypox virus agents

T. Hishiki, T. Morita, D. Akazawa, H. Ohashi, E.-S. Park, M. Kataoka, J. Mifune, K. Shionoya, K. Tsuchimoto, S. Ojima, A. H. Azam, S. Nakajima, T. Yoshikawa, M. Shimojima, K. Kiga, , K. Watashi

This study identifies IMPDH as a potential target for anti-monkeypox virus agents by showing that compounds targeting this enzyme inhibit MPXV replication more effectively than existing treatments.

bioRxiv · Dec 26, 2022 · PreprintMicrobiology

Potential anti-monkeypox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatments

D. Akazawa, H. Ohashi, T. Hishiki, T. Morita, S. Iwanami, K. S. Kim, Y. D. Jeong, E.-S. Park, M. Kataoka, K. Shionoya, J. Mifune, K. Tsuchimoto, S. Ojima, A. H. Azam, S. Nakajima, , K. Watashi

This study identifies atovaquone, mefloquine, and molnupiravir as potential anti-monkeypox virus drugs, with atovaquone showing enhanced efficacy when combined with tecovirimat.

bioRxiv · Aug 2, 2022 · PreprintMicrobiology

Helicobacter small RNA regulates host adaptation and carcinogenesis

R. Kinoshita-Daitoku, K. Kiga, R. Otsubo, Y. Ogura, T. Sanada, Z. Bo, T. V. Phuoc, T. Okano, T. Iida, R. Yokomori, E. Kuroda, S. Hirukawa, M. Tanaka, A. Sood, P. Subsomwong, , H. Mimuro

This study identifies HPnc4160, a small RNA in H. pylori, that negatively regulates host adaptation and gastric cancer by modulating gene expression and bacterial colonization.

bioRxiv · Feb 15, 2020 · PreprintMicrobiology

Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

K. Kiga, X.-E. Tan, R. Ibarra-Chavez, S. Watanabe, Y. Aiba, Y. Sato, F.-Y. Li, T. Sasahara, B. Cui, M. Kawauchi, T. Boonsiri, K. Thitiananpakorn, Y. Taki, A. H. Azam, M. Suzuki, , L. Cui

This study develops CRISPR-Cas13a-based antimicrobials that kill target bacteria by cleaving RNA, showing effectiveness against carbapenem-resistant E. coli and methicillin-resistant S. aureus.

bioRxiv · Nov 18, 2019Microbiology

Composition and Diversity of CRISPR-Cas13a systems in the genus Leptotrichia

S. Watanabe, B. Cui, K. Kiga, Y. Aiba, X.-E. Tan, Y. Sato'o, M. Kawauchi, T. Boonsiri, K. Thitiananpakorn, Y. Taki, F.-Y. Li, A. H. Azam, Y. Nakada, T. Sasahara, L. Cui

The paper analyzes CRISPR-Cas13a and other CRISPR-Cas systems in 11 Leptotrichia strains, revealing their diversity, distribution, and evolutionary relationships.

bioRxiv · Jul 22, 2019Microbiology