T. Iida

Direct Observation of Stepping Rotation of V-ATPase Reveals Rigid Coupling between Vo and V1 Motors

The paper observes ATP-driven stepping rotation of V-ATPase mutants using a gold nanoparticle probe, revealing rigid coupling between Vo and V1 motors through distinct pausing positions and step dynamics.

Conversion of cancer-associated fibroblasts from pro- to antitumor improves the sensitivity of pancreatic cancer to chemotherapeutics

This study converts pro-tumor CAFs to anti-tumor CAFs using Meflin induction, enhancing PDAC chemosensitivity through improved drug delivery and reduced tissue stiffness.

CBL-C E3 ubiquitin ligase acts as a host defense to mediate ubiquitin-proteasomal degradation of enteropathogenic Escherichia coli Tir protein

The paper shows that CBL-C ubiquitin ligase targets Tir protein for proteasomal degradation, reducing EPEC colonization.

Diagnosis of central serous chorioretinopathy by deep learning analysis of en face images of choroidal vasculature

This study uses deep learning to classify central serous chorioretinopathy from OCT images, achieving high accuracy with different models and showing DL focuses on choroidal vessel regions.

De Novo Design of Allosteric Control into Rotary Motor V1-ATPase by Restoring Lost Function

The paper designs allosteric control into V1-ATPase by restoring lost ATP binding function in pseudo-enzyme subunits, showing tunable acceleration through modulated binding affinity.

Helicobacter small RNA regulates host adaptation and carcinogenesis

This study identifies HPnc4160, a small RNA in H. pylori, that negatively regulates host adaptation and gastric cancer by modulating gene expression and bacterial colonization.

Soil prokaryotes associated with decreasing pathogen density during anaerobic soil disinfestation

The paper examines how soil microbial communities change during anaerobic soil disinfestation and identifies specific microbes linked to pathogen reduction.

Comparison of prokaryotic communities among fields exhibiting different disinfestation effects by anaerobic soil disinfestation

The paper compares prokaryotic communities in soils with different disinfestation effects after anaerobic soil disinfestation, finding specific microbial changes associated with effective disinfestation.

Bile Acid Biosynthesis Avoiding Cholesterol

The paper identifies a novel bile acid biosynthesis pathway in Smith-Lemli-Opitz syndrome that bypasses cholesterol, starting from 7-dehydrocholesterol, and links intermediates to Hedgehog signaling.