Serine ubiquitination of p62 regulates Nrf2 dependent redox homeostasis
R. Mukherjee, M. Hoffmann, A. Gonzalez, A. Bhattacharya, S. K. Kuncha, R. Rathore, D. Shin, T. Colby, I. Matic, M. Misra, I. Dikic
This study shows that serine ubiquitination of p62 by Legionella pneumophila SidE effectors inhibits Nrf2 signaling, altering redox homeostasis and host metabolism during infection.
bioRxiv · Jun 17, 2023 · PreprintCell Biology