BiochemistrybioRxivPreprint
Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate
C. Iserman, C. A. Roden, M. Boerneke…·A. Gladfelter
This study shows SARS-CoV-2 N-protein forms liquid-liquid phase separation with specific viral RNA sequences, which is temperature-sensitive and can be modulated by small molecules, offering potential for antiviral drug development.
DOI 10.1101/2020.06.11.147199