Defective Function of α-Ketoglutarate Dehydrogenase Exacerbates Mitochondrial ATP Deficits during Complex I Deficiency
G. G. Piroli, A. M. Manuel, R. S. McCain, H. H. Smith, O. Ozohanics, S. Mellid, W. E. Cotham, M. D. Walla, A. Cascon, A. Ambrus, N. Frizzell
This study shows that defective α-ketoglutarate dehydrogenase function worsens mitochondrial ATP deficits in Complex I deficiency by impairing TCA cycle components.
bioRxiv · Jan 9, 2020Biochemistry