Author

N. Frizzell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

A. Alpsoy· 1 shared A. Ambrus· 1 shared A. Bavari· 1 shared A. Cascon· 1 shared A. L. Thorpe· 1 shared A. M. Manuel· 1 shared C. A. Briney· 1 shared D. W. Bak· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Alpsoy

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Author profile →

2 papers

Recent·Most cited

Defective Function of α-Ketoglutarate Dehydrogenase Exacerbates Mitochondrial ATP Deficits during Complex I Deficiency

G. G. Piroli, A. M. Manuel, R. S. McCain, H. H. Smith, O. Ozohanics, S. Mellid, W. E. Cotham, M. D. Walla, A. Cascon, A. Ambrus, N. Frizzell

This study shows that defective α-ketoglutarate dehydrogenase function worsens mitochondrial ATP deficits in Complex I deficiency by impairing TCA cycle components.

bioRxiv · Jan 9, 2020Biochemistry

A chemoproteomic portrait of the oncometabolite fumarate

R. A. Kulkarni, D. W. Bak, D. Wei, S. E. Bergholtz, C. A. Briney, J. H. Shrimp, A. L. Thorpe, A. Bavari, A. Alpsoy, M. Levy, L. Florens, M. P. Washburn, E. C. Dykhuizen, N. Frizzell, E. Weerapana, , J. L. Meier

This study maps fumarate's covalent targets using chemoproteomic probes and identifies cysteine residues affected by fumarate or FH mutations in HLRCC cells.

bioRxiv · Mar 22, 2018Cancer Biology