Synovial fibroblast niche shapes the efficacy - safety dynamics of JAK inhibition in rheumatoid arthritis
Ana Županič, Sam G. Edalat, Blaž Burja, Miriam Paulina Busch, Tadeja Kuret, Nadja Ižanc, R. S. Zingg, Laura M. Merlo Pich, Snežna Sodin‐Šemrl, Oliver Distler, Miranda Houtman, Caroline Ospelt, Reto Gerber, Mark D. Robinson, Mojca Frank‐Bertoncelj
This study identifies synovial fibroblasts as key targets of JAK inhibition in RA and reveals cytokine- and drug-driven mechanisms affecting JAKi efficacy and safety.
bioRxiv · Mar 25, 2026 · PreprintMolecular Biology