Author

Sam G. Edalat

University of Zurich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Caroline OspeltiD· 3 shared Miranda HoutmaniD· 3 shared Mojca Frank‐BertonceljiD· 3 shared Oliver DistleriD· 3 shared Blaž Burja· 2 shared Chantal PauliiD· 2 shared Kristina BuerkiiD· 2 shared Mark D. RobinsoniD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Caroline OspeltORCID

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Author profile →

3 papers

Recent·Most cited

Synovitis in systemic sclerosis is an interferon-driven stromal condition distinct from rheumatoid arthritis

Celina Geiß, Camino Calvo-Cebrián, Miranda Houtman, Ege Ezen, Katerina Apostolopoulou, Cristian Iperi, Melpomeni Toitou, Alexandra A. Khmelevskaya, Marija Lugar, Anne Cauvet, Yannis Djeffal, Mojca Frank‐Bertoncelj, Sam G. Edalat, Thomas Rauer, Katharina Zachariassen, , Muriel Elhaï

This study identifies SSc synovitis as an IFN-driven stromal condition distinct from RA, with implications for IFNAR1 blockade as a therapeutic strategy.

bioRxiv · Jul 2, 2026 · PreprintImmunology

Synovial fibroblast niche shapes the efficacy - safety dynamics of JAK inhibition in rheumatoid arthritis

Ana Županič, Sam G. Edalat, Blaž Burja, Miriam Paulina Busch, Tadeja Kuret, Nadja Ižanc, R. S. Zingg, Laura M. Merlo Pich, Snežna Sodin‐Šemrl, Oliver Distler, Miranda Houtman, Caroline Ospelt, Reto Gerber, Mark D. Robinson, Mojca Frank‐Bertoncelj

This study identifies synovial fibroblasts as key targets of JAK inhibition in RA and reveals cytokine- and drug-driven mechanisms affecting JAKi efficacy and safety.

bioRxiv · Mar 25, 2026 · PreprintMolecular Biology

A reference single-cell map of freshly dissociated human synovium in inflammatory arthritis with an optimized dissociation protocol for prospective synovial biopsy collection

Sam G. Edalat, Reto Gerber, Miranda Houtman, Janine Lückgen, Rui Lourenço Teixeira, Maria Del Pilar Palacios Cisneros, Tamara Pfanner, Tadeja Kuret, Nadja Ižanc, Raphael Micheroli, Joaquim Polido Pereira, Fernando Saraiva, Swathi Lingam, Kristina Bürki, Blaž Burja, , Mojca Frank‐Bertoncelj

The paper optimizes a dissociation protocol for fresh synovial biopsies and creates a single-cell reference map of human synovium in inflammatory arthritis, revealing new cell types and functions.

iScience · Apr 10, 2024Peer-reviewedGenomics