Caroline Ospelt

Development of a multi-organ single-cell atlas of systemic sclerosis reveals shared and tissue-specific pathogenic pathways.

This study creates a multi-organ single-cell atlas of systemic sclerosis to identify shared and tissue-specific transcriptional programs and potential therapeutic targets.

Conserved Fibroblast Subsets Drive Shared Fibrotic Mechanisms in Osteoarthritis Synovium and Systemic Sclerosis Skin

This study identifies conserved fibroblast subsets and fibrotic mechanisms in osteoarthritis and systemic sclerosis using single-cell RNA-seq and spatial transcriptomics.

Synovitis in systemic sclerosis is an interferon-driven stromal condition distinct from rheumatoid arthritis

This study identifies SSc synovitis as an IFN-driven stromal condition distinct from RA, with implications for IFNAR1 blockade as a therapeutic strategy.

Developing High Content Imaging Functional Panels to Characterize Synovial Fibroblasts in Rheumatoid Arthritis

This paper develops a high-content imaging assay to analyze synovial fibroblasts in arthritis, revealing disease-specific functional heterogeneity and identifying IL-1β as a key driver of autophagy.

Human Fibroblast-Myeloid cell tissue atlas across lung, synovium, skin and heart

The paper analyzes scRNAseq data from multiple tissues to identify shared and tissue-specific myeloid and stromal cell populations in health and disease.

Metabolic-secretory decoupling defines a disease-intrinsic state in rheumatoid arthritis monocytes

The paper identifies a stable metabolic-secretory defect in RA monocytes across activation states using multi-omics analysis, linking reduced glycosylation to disease mechanisms.

SNPic: SNP Topic Modeling for Interpretable Clustering of Complex phenotypes

SNPic uses topic modeling to cluster complex phenotypes by interpreting GWAS data as a corpus, identifying interpretable genetic modules and biological mechanisms.

Autophagy shapes the peptide repertoire of rheumatoid arthritis-associated HLA class II alleles

This study shows autophagy contributes to MHC class II presentation of RA-related peptides in HLA-DRB1*04:01 alleles, with 30% of peptides differing between autophagy sufficient and deficient cells.

Synovial fibroblast niche shapes the efficacy - safety dynamics of JAK inhibition in rheumatoid arthritis

This study identifies synovial fibroblasts as key targets of JAK inhibition in RA and reveals cytokine- and drug-driven mechanisms affecting JAKi efficacy and safety.

Disease-specific fibroblast-myeloid interactions in rheumatoid arthritis synovium

This study identifies disease-specific fibroblast-myeloid interactions in RA synovium, showing SPP1 signaling and fibroblast-myeloid-dendritic interactions drive RA inflammation by linking innate immunity to autoimmunity.

Distinct myeloid precursors and their interaction with mesenchymal cells orchestrate the spreading of psoriatic disease from the skin to the joints

The paper identifies a unique myeloid precursor population that facilitates the spread of psoriatic inflammation from skin to joints, interacting with fibroblasts to regulate T cell IL-17 expression.

5' HOXD Genes Differentially Regulate Gene Expression of Synovial Fibroblasts in Hand Joints

The paper shows that HOXD13 regulates gene expression in synovial fibroblasts, influencing primary cilia function and joint-specific RA pathology.

A reference single-cell map of freshly dissociated human synovium in inflammatory arthritis with an optimized dissociation protocol for prospective synovial biopsy collection

The paper optimizes a dissociation protocol for fresh synovial biopsies and creates a single-cell reference map of human synovium in inflammatory arthritis, revealing new cell types and functions.