Author

R. Sabouny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Khan· 2 shared A. Ravandi· 2 shared F. Iqbal· 2 shared P. Machiraju· 2 shared S. C. Greenway· 2 shared T. Shutt· 2 shared T. Zhao· 2 shared A. Lodha· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

A. Khan

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Author profile →

3 papers

Recent·Most cited

Mitochondrial fission is required for proper nucleoid distribution within mitochondrial networks

H. S. Ilamathi, M. Ouellet, R. Sabouny, J. Desrochers-Goyette, M. A. Lines, G. Pfeffer, T. E. SHUTT, M. Germain

This study develops a computational tool to analyze nucleoid distribution in mitochondrial networks and shows that mitochondrial fission is essential for proper nucleoid positioning and distribution.

bioRxiv · Mar 17, 2021 · PreprintCell Biology

Reversible Mitochondrial Fragmentation in iPSC-Derived Cardiomyocytes from Children with DCMA, a Mitochondrial Cardiomyopathy

L. Rohani, P. Machiraju, R. Sabouny, G. Meng, S. Liu, T. Zhao, F. Iqbal, A. Ravandi, J. C. Wu, A. Khan, T. Shutt, D. Rancourt, S. C. Greenway

This study uses iPSC-derived cardiomyocytes from DCMA patients to show reversible mitochondrial fragmentation and OPA1 isoform imbalance, suggesting SS-31 as a potential therapy.

Canadian Journal of Cardiology · Apr 1, 2020Peer-reviewedCell Biology

SS-31 Reverses Mitochondrial Fragmentation in Fibroblasts from Patients with DCMA, a Mitochondrial Cardiomyopathy

P. Machiraju, X. Wang, R. Sabouny, J. Huang, T. Zhao, F. Iqbal, M. King, D. Prasher, A. Lodha, A. Ravandi, B. Argiropoulos, D. Sinasac, A. Khan, T. Shutt, S. C. Greenway

This study shows that SS-31 reverses mitochondrial fragmentation and increases ROS in DCMA fibroblasts, suggesting it as a potential therapy for this mitochondrial cardiomyopathy.

bioRxiv · Jun 17, 2019Cell Biology