S. C. Greenway

Altered glutamine metabolism of cultured fibroblasts predicts severity of cardiac dysfunction in the dilated cardiomyopathy with ataxia syndrome (DCMA), a mitochondrial cardiomyopathy

The paper identifies altered glutamine and lactate metabolism in DCMA patient fibroblasts as a predictor of cardiac dysfunction severity.

Reversible Mitochondrial Fragmentation in iPSC-Derived Cardiomyocytes from Children with DCMA, a Mitochondrial Cardiomyopathy

This study uses iPSC-derived cardiomyocytes from DCMA patients to show reversible mitochondrial fragmentation and OPA1 isoform imbalance, suggesting SS-31 as a potential therapy.

Early Inhibition of Retinoic Acid Signaling Rapidly Generates Cardiomyocytes Expressing Ventricular Markers from Human Induced Pluripotent Stem Cells

This study shows that inhibiting retinoic acid signaling early in differentiation rapidly generates ventricular-like cardiomyocytes from human iPSCs with higher MLC2V expression.

SS-31 Reverses Mitochondrial Fragmentation in Fibroblasts from Patients with DCMA, a Mitochondrial Cardiomyopathy

This study shows that SS-31 reverses mitochondrial fragmentation and increases ROS in DCMA fibroblasts, suggesting it as a potential therapy for this mitochondrial cardiomyopathy.

Vancomycin Relieves Mycophenolate Mofetil-Induced Gastrointestinal Toxicity by Eliminating Gut Bacterial β-Glucuronidase Activity

This study shows vancomycin reduces MMF-induced GI toxicity by inhibiting gut bacterial β-glucuronidase activity, preventing MPA conversion from its glucuronidated form.