Author

J. C. Wu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 8 Organism:human· 8 Approach:experimental assay· 7 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

M. K. Ali· 2 shared Y. Liu· 2 shared A. Brunet· 1 shared A. Cao· 1 shared A. F. McGuire· 1 shared A. Khan· 1 shared A. Lieu· 1 shared A. Liu· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersCell Biology

M. K. Ali

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

R. Janicot, M. Maziarz, J.-C. Park, A. Luebbers, E. Green, J. Zhao, C. E. Philibert, H. Zhang, M. D. Layne, J. C. Wu, M. Garcia-Marcos

The paper develops a biosensor platform to measure GPCR activity in various contexts, revealing insights into coupling selectivity, pharmacogenomics, and signaling bias.

Cell · Mar 1, 2024Peer-reviewedBiochemistry

Structure of the Thin Filament in Human iPSC-derived Cardiomyocytes and its Response to Heart Disease

R. A. Woldeyes, M. Nishiga, A. S. Vander Roest, L. Engel, P. Giri, G. C. Montenegro, A. R. Dunn, J. A. Spudich, D. Bernstein, M. F. Schmid, J. C. Wu, W. Chiu

This study uses cryo-ET to analyze the structure of thin filaments in human iPSC-derived cardiomyocytes and how they change with disease-related perturbations.

bioRxiv · Oct 26, 2023 · PreprintBiophysics

The Effect of E-Cigarettes on the Human Heart Studied using Cardiomyocytes Generated from Induced Pluripotent Stem Cells

A. T. Bhowmik, S. R. Zhao, J. C. Wu

This study quantitatively assesses e-cigarette toxicity on human cardiomyocytes, showing increased cardiotoxicity with higher nicotine concentrations and faster decline in diseased cells.

bioRxiv · Apr 6, 2023 · PreprintCell Biology

Identifying transcriptomic downstream targets of genes commonly mutated in Hereditary Hemorrhagic Telangiectasia

M. K. Ali, Y. Liu, K. Schimmel, N. H. Juul, C. A. Stockman, J. C. Wu, E. Spiekerkoetter

This study identifies common downstream transcriptomic targets of HHT-causing genes and discovers Brivanib as a potential therapeutic for HHT.

bioRxiv · Nov 25, 2022 · PreprintCell Biology

Long non-coding RNA RGMB-AS1 as a novel modulator of Bone Morphogenetic Protein Receptor 2 signaling in pulmonary arterial hypertension

M. K. Ali, Y. Liu, J. C. Wu, V. d. J. Perez, C. J. Rhodes, A. Cao, M. R. Wilkins, M. R. Nicolls, E. F. Spiekerkoetter

This study identifies RGMB-AS1 as an upregulated lncRNA in PAH that modulates BMPR2 signaling and improves vascular cell function when inhibited.

bioRxiv · Aug 27, 2022 · PreprintCell Biology

Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging

L. Liu, S. Kim, M. T. Buckley, J. M. Reyes, J. Kang, L. Tian, T. Wang, A. Lieu, M. Mao, C. Mateo-Rodriguez, H. Ishak, M. Jeong, J. C. Wu, M. A. Goodell, A. Brunet, T. A. Rando

This study examines how exercise affects stem cell compartments and immune cells in aging mice, identifying rejuvenating effects and transcriptomic changes.

bioRxiv · Jan 12, 2022Cell Biology

Nanocrown electrodes for reliable and robust intracellular recording of cardiomyocytes and cardiotoxicity screening

Z. Jahed, Y. Yang, C.-T. Tsai, E. P. Foster, A. F. McGuire, H. Yang, A. Liu, C. Forro, Z. Yan, X. Jiang, M.-T. Zhao, W. Zheng, X. Li, T. Li, A. Pawlosky, , B. Cui

This paper develops nanocrown electrodes for reliable intracellular recording of cardiomyocytes and demonstrates their use in cardiotoxicity screening.

bioRxiv · Sep 28, 2021 · PreprintBioengineering

A red fluorescent protein with improved monomericity enables ratiometric voltage imaging with ASAP3

B. B. Kim, H. Wu, Y. A. Hao, M. Pan, M. Chavarha, M. Westberg, F. St-Pierre, J. C. Wu, M. Lin

The paper develops a ratiometric voltage indicator by fusing an improved red fluorescent protein to ASAP3, enabling motion artifact-free voltage imaging in motile cells.

bioRxiv · Oct 9, 2020Cell Biology

Reversible Mitochondrial Fragmentation in iPSC-Derived Cardiomyocytes from Children with DCMA, a Mitochondrial Cardiomyopathy

L. Rohani, P. Machiraju, R. Sabouny, G. Meng, S. Liu, T. Zhao, F. Iqbal, A. Ravandi, J. C. Wu, A. Khan, T. Shutt, D. Rancourt, S. C. Greenway

This study uses iPSC-derived cardiomyocytes from DCMA patients to show reversible mitochondrial fragmentation and OPA1 isoform imbalance, suggesting SS-31 as a potential therapy.

Canadian Journal of Cardiology · Apr 1, 2020Peer-reviewedCell Biology

An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans

N. Sayed, T. Gao, R. j. Tibshirani, T. Hastie, L. Cui, T. Kuznetsova, Y. Rosenberg-Hasson, R. Ostan, D. Monti, B. Lehallier, S. Shen-Orr, H. Maecker, C. L. Dekker, T. Wyss-Coray, C. Franceschi, , D. Furman

The paper develops an inflammatory clock of aging (iAge) using blood immunome data from 1001 individuals, showing it correlates with multi-morbidity, immunosenescence, and cardiovascular aging.

bioRxiv · Nov 16, 2019 · PreprintImmunology