Author

R. Sanishvili

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Organism:human· 1

Frequent Co-Authors

A. Bellina· 1 shared C. M. Jenkins· 1 shared C.-X. Wu· 1 shared I. Miller· 1 shared J. Liao· 1 shared K. R. Malley· 1 shared L. Wan· 1 shared M. Federici· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. Bellina

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2 papers

Recent·Most cited

A revised 1.6 Å structure of the GTPase domain of the Parkinson’s disease-associated protein LRRK2 provides insights into mechanisms

C.-X. Wu, J. Liao, Y. Park, N. C. Hoang, V. A. Engel, L. Wan, M. Oh, R. Sanishvili, Y. Takagi, S. M. Johnson, M. Wang, M. Federici, R. J. Nichols, A. Bellina, X. Reed, , Q. Q. Hoang

This paper reports a 1.6 Å crystal structure of the GTPase domain of LRRK2, revealing how PD-associated mutations at Arg-1441 impair nucleotide-dependent conformational dynamics.

bioRxiv · Jun 23, 2019 · PreprintBiochemistry

A novel dimeric active site and regulation mechanism revealed by the crystal structure of iPLA2β

K. R. Malley, O. Koroleva, I. Miller, R. Sanishvili, C. M. Jenkins, R. W. Gross, S. Korolev

The paper presents the first crystal structure of iPLA2β, revealing a dimeric active site and regulation mechanism that could inform therapeutic inhibitor development.

bioRxiv · Sep 29, 2017Biochemistry