R. J. Nichols

Carbon isotope fractionation by an ancestral rubisco suggests biological proxies for CO2 through geologic time should be re-evaluated

The paper measures carbon isotope fractionation of an ancestral rubisco in cyanobacteria, showing that evolutionary changes in photosynthesis physiology, not just atmospheric CO2, affect the carbon isotope record.

The encapsulin from Thermatoga maritima is a flavoprotein with a symmetry matched ferritin-like cargo protein

This study investigates the structure and function of the T. maritima encapsulin, revealing its role in cargo protein encapsulation and enzymatic activity through symmetry-matching and flavin binding.

A nanocompartment containing the peroxidase DypB contributes to defense against oxidative stress in M. tuberculosis

This study identifies a nanocompartment in M. tuberculosis containing DypB that enhances resistance to oxidative stress during infection and antibiotic treatment.

Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism

The paper identifies a new prokaryotic nanocompartment in Synechococcus elongatus that enhances cysteine desulfurase activity during sulfate starvation.

A revised 1.6 Å structure of the GTPase domain of the Parkinson’s disease-associated protein LRRK2 provides insights into mechanisms

This paper reports a 1.6 Å crystal structure of the GTPase domain of LRRK2, revealing how PD-associated mutations at Arg-1441 impair nucleotide-dependent conformational dynamics.