Author

S. M. Johnson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Assay:protein structure· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. Anderson· 1 shared A. Banyard· 1 shared A. Bellina· 1 shared A. Harthorn· 1 shared A. K. Lewis· 1 shared A. Mironov· 1 shared B. J. Hackel· 1 shared C. McMahon· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperPhysiology

A. Anderson

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Author profile →

5 papers

Recent·Most cited

Chemically induced partial unfolding of the multifunctional Apurinic/apyrimidinic endonuclease 1

R. Rai, O. Dawodu, J. Meng, S. M. Johnson, J. Z. Vilseck, M. R. Kelley, J. J. Ziarek, M. M. Georgiadis

This study investigates how the redox inhibitor APX3330 induces reversible partial unfolding of APE1, revealing structural changes relevant to its redox function.

Protein Science · May 15, 2025Peer-reviewedBiochemistry

Substrate-Specific Function of PNPLA3 Facilitates Hepatic VLDL-Triglyceride Secretion During Stimulated Lipogenesis

S. M. Johnson, H. Bao, C. McMahon, Y. Chen, S. Burr, A. Anderson, K. Madeyski-Bengtson, D. Linden, X. Han, J. Liu

This study defines the physiological role of wild-type PNPLA3 in maintaining hepatic VLDL-TG secretion and shows that the I148M variant impairs this function during lipogenic conditions.

bioRxiv · Aug 30, 2023 · PreprintPhysiology

Engineered protein-small molecule conjugates empower selective enzyme inhibition

A. K. Lewis, A. Harthorn, S. M. Johnson, R. R. Lobb, B. J. Hackel

The paper introduces a platform to create protein-small molecule hybrids (PriSMs) that enhance enzyme inhibition specificity and potency compared to small molecules or proteins alone.

bioRxiv · May 5, 2021Bioengineering

Large extracellular vesicles can be characterised by multiplex labelling using imaging flow cytometry

S. M. Johnson, A. Banyard, C. Smith, A. Mironov, M. G. McCabe

The paper develops a method to isolate and characterize large extracellular vesicles using imaging flow cytometry, showing a correlation between EV size and marker expression.

bioRxiv · Feb 7, 2020Cell Biology

A revised 1.6 Å structure of the GTPase domain of the Parkinson’s disease-associated protein LRRK2 provides insights into mechanisms

C.-X. Wu, J. Liao, Y. Park, N. C. Hoang, V. A. Engel, L. Wan, M. Oh, R. Sanishvili, Y. Takagi, S. M. Johnson, M. Wang, M. Federici, R. J. Nichols, A. Bellina, X. Reed, , Q. Q. Hoang

This paper reports a 1.6 Å crystal structure of the GTPase domain of LRRK2, revealing how PD-associated mutations at Arg-1441 impair nucleotide-dependent conformational dynamics.

bioRxiv · Jun 23, 2019 · PreprintBiochemistry