Cell BiologybioRxiv
Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes
A. Bochynska, A. T. Stenzel, R. Sayadi Boroujeni…·B. Luscher
This study shows that loss of Ash2l in mouse fibroblasts reduces H3K4 methylation and gene expression, leading to senescence independent of SASP, with FoxM1-responsive genes involved.
DOI 10.1093/nar/gkac591