Author

I. G. Costa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

M. Zenke· 2 shared R. Li· 2 shared W. Wagner· 2 shared A. Benabid· 1 shared A. Bochynska· 1 shared A. Maurer· 1 shared A. T. Stenzel· 1 shared A. Theocharides· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

M. Zenke

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cancer-associated fibroblasts reveal aberrant DNA methylation across different types of cancer

M. Schmidt, T. Maie, I. G. Costa, W. Wagner

The paper identifies aberrant DNA methylation in cancer-associated fibroblasts across multiple cancer types and links these changes to patient prognosis.

bioRxiv · Feb 2, 2024Cancer Biology

Neonatal Peyer's patch cDC activation as a pacemaker of postnatal immune maturation

N. Torow, R. Li, T. Hitch, C. Mingels, S. Al Bounny, N. van Best, E.-L. Stange, A. Benabid, L. Ruettger, M. Gadermayr, S. Runge, N. Treichel, D. Merhof, S. Rosshart, N. Jehmlich, , M. W. Hornef

This study identifies neonatal Peyer's patch mononuclear phagocytes as a key driver of postnatal immune maturation and shows that targeted interventions can modulate mucosal immune responses.

bioRxiv · Mar 3, 2022 · PreprintImmunology

The spatial self-organization within pluripotent stem cell colonies is continued in detaching aggregates

M. H. Elsafi Mabrouk, R. Goetzke, G. Abagnale, B. Yesilyurt, L. Salz, K. Zeevaert, Z. Ma, M. A. S. Toledo, R. Li, I. G. Costa, V. Pachauri, U. Schnakenberg, M. Zenke, W. Wagner

The paper shows that self-organization in iPSC colonies continues in 3D aggregates formed after detachment from substrates, with maintained gene expression patterns.

Biomaterials · Mar 1, 2022Peer-reviewedCell Biology

Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes

A. Bochynska, A. T. Stenzel, R. Sayadi Boroujeni, C.-C. Kuo, M. Barsoum, W. Liang, P. Bussmann, I. G. Costa, J. Luscher-Firzlaff, B. Luscher

This study shows that loss of Ash2l in mouse fibroblasts reduces H3K4 methylation and gene expression, leading to senescence independent of SASP, with FoxM1-responsive genes involved.

bioRxiv · Feb 11, 2022Cell Biology

CALR frameshift mutations in MPN patient-derived iPS cells accelerate maturation of megakaryocytes

K. Olschok, L. Han, M. A. S. de Toledo, J. Boehnke, M. Grasshoff, I. G. Costa, A. Theocharides, A. Maurer, H. M. Schueler, E. M. Buhl, K. Pannen, J. Baumeister, M. Kalmer, S. Gupta, P. Boor, , S. Koschmieder

This study shows CALR mutations in iPS cells from MPN patients accelerate megakaryocyte maturation and identify hypoxia signaling as a therapeutic target.

Stem Cell Reports · Nov 1, 2021Peer-reviewedCancer Biology