Author

C.-C. Kuo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Ecology· 3 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 5 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Research Focus:ecology & biodiversity· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

H.-C. Shih· 2 shared J.-K. Wang· 2 shared M. Zenke· 2 shared N. E. Lewis· 2 shared S. Li· 2 shared A. Bochynska· 1 shared A. S. Rosenberg· 1 shared A. T. Stenzel· 1 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersEcology

H.-C. Shih

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis

H.-Y. Hsiao, C.-C. Cheng, Y.-T. Chou, C.-C. Kuo, W.-C. Wang, B. P. Sampurna, Y.-W. Wang, C.-L. Hsiao, J.-Y. Wu, K.-H. Lin, W.-Y. Yang, Y.-H. Lin, K.-H. Gwee, H.-D. Wang, C.-H. Yuh

This study identifies the STAT3/AMPK/PFKL axis in liver cancer, showing how it promotes glycolysis and tumor growth through stabilization of PFKL and RPIA in glycolytic bodies.

bioRxiv · Feb 29, 2024 · PreprintCancer Biology

A lncRNA identifies IRF8 enhancer element in negative feedback control of dendritic cell differentiation

H. Xu, Z. Li, C.-C. Kuo, K. Goetz, T. Look, M. A. Szymanski de Toledo, K. Sere, I. Gesteira Costa Filho, M. Zenke

The paper identifies a long non-coding RNA that regulates IRF8 autoactivation through a negative feedback loop in dendritic cell differentiation.

bioRxiv · Aug 11, 2022Cell Biology

Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes

A. Bochynska, A. T. Stenzel, R. Sayadi Boroujeni, C.-C. Kuo, M. Barsoum, W. Liang, P. Bussmann, I. G. Costa, J. Luscher-Firzlaff, B. Luscher

This study shows that loss of Ash2l in mouse fibroblasts reduces H3K4 methylation and gene expression, leading to senescence independent of SASP, with FoxM1-responsive genes involved.

bioRxiv · Feb 11, 2022Cell Biology

DNMT3A knockouts in human iPSCs prevent de novo DNA methylation and reveal growth advantage during hematopoietic differentiation

O. Cypris, J. Franzen, J. Frobel, P. Glueck, C.-C. Kuo, S. Schmitz, S. Nuechtern, M. Zenke, W. Wagner

bioRxiv · Dec 15, 2021Cell Biology

Do pesticide residues have enduring negative effect on macroinvertebrates and vertebrates in fallow rice paddies?

J.-S. Song, C.-C. Kuo

This study compares pesticide effects on macroinvertebrates and vertebrates in organic vs. conventional rice fields during cultivation and fallow periods, finding higher invertebrate richness in organic fields during cultivation but similar results during fallow.

bioRxiv · Jul 6, 2021 · PreprintEcology

Commensal rodent habitat expansion enhances arthropod disease vectors on a tropical volcanic island

D.-L. Wu, H.-C. Shih, J.-K. Wang, H.-J. Teng, C.-C. Kuo

The paper shows that invasive rats on a tropical island increase chigger abundance and scrub typhus risk by altering habitat and facilitating parasite transmission.

bioRxiv · Apr 20, 2021Ecology

Restoration of deficient DNA Repair Genes Mitigates Genome Instability and Increases Productivity of Chinese Hamster Ovary Cells

P. Spahn, X. Zhang, Q. Hu, N. Hamaker, H. Hefzi, S. Li, C.-C. Kuo, Y. Huang, J. Lee, P. Ly, K. Lee, N. E. Lewis

This study restores DNA repair genes in CHO cells, improving genome stability and protein titer.

bioRxiv · Jan 7, 2021 · PreprintCell Biology

Invasive plants facilitated by socioeconomic change shelter vectors of scrub typhus and spotted fever

C.-Y. Wei, J.-K. Wang, H.-C. Shih, H.-C. Wang, C.-C. Kuo

This study shows that invasive plants, driven by socioeconomic changes, create habitats that support higher populations of disease vectors, increasing the risk of scrub typhus and spotted fever.

bioRxiv · Jun 5, 2019Ecology

Combating viral contaminants in CHO cells by engineering STAT1 mediated innate immunity

A. W. T. Chiang, S. Li, B. P. Kellman, G. Chattopadhyay, Y. Zhang, C.-C. Kuo, J. M. Gutierrez, F. Ghazi, H. Schmeisser, P. Menard, S. Petersen Bjorn, B. G. Voldborg, A. S. Rosenberg, M. Puig, N. E. Lewis

The paper identifies Gfi1 and Trim24 as repressors of STAT1 in CHO cells and shows that knocking them out increases resistance to RNA viruses.

bioRxiv · Sep 21, 2018Bioengineering