Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma
K. Helmsauer, M. Valieva, S. Ali, R. Chamorro Gonzalez, R. Schoepflin, C. Roeefzaad, Y. Bei, H. Dorado Garcia, E. Rodriguez-Fos, M. Puiggros, V. Heinrich, M. Robson, K. Kasack, K. Haase, L. P. Kuschel, , R. P. Koche
The paper identifies two distinct MYCN amplicon structures in neuroblastoma, showing how enhancer hijacking compensates for loss of local regulatory elements.
bioRxiv · Dec 20, 2019Cancer Biology