V. Heinrich

Integrative experimental/computational approach establishes active cellular protrusion as the primary driving force of phagocytic spreading by immune cells

This paper develops a computational framework to assess the role of active protrusion versus passive adhesion in immune cell phagocytic spreading, finding that protrusion is the primary driver.

Mechanisms of frustrated phagocytic spreading of human neutrophils on antibody-coated surfaces

The paper analyzes neutrophil spreading on antibody-coated surfaces, finding that cytoskeletal forces, not adhesion, primarily drive phagocytic spreading.

Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma

The paper identifies two distinct MYCN amplicon structures in neuroblastoma, showing how enhancer hijacking compensates for loss of local regulatory elements.

Maternal antibodies provide strain-specific protection against infection with the Lyme disease pathogen in a wild rodent

This study shows that maternal antibodies from infected bank voles protect offspring against the same strain of Borrelia afzelii but not a different strain.