Author

E. Rodriguez-Fos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:DNA methylation· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. Haase· 3 shared A. Eggert· 2 shared A. G. Henssen· 2 shared A. Henssen· 2 shared D. Torrents· 2 shared H. Dorado Garcia· 2 shared K. Helmsauer· 2 shared M. Giurgiu· 2 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

K. Haase

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Author profile →

4 papers

Recent·Most cited

Decoil: Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data

M. Giurgiu, N. Wittstruck, E. Rodriguez-Fos, R. Chamorro Gonzalez, L. Bruckner, A. Krienelke-Szymansky, K. Helmsauer, A. Hartebrodt, R. P. Koche, K. Haase, K. Reinert, A. G. Henssen

Decoil reconstructs complex extrachromosomal DNA structures from long-read sequencing data, improving resolution of ecDNA topology and heterogeneity in cancer.

bioRxiv · Nov 15, 2023Cancer Biology

Amplicon structure creates collateral therapeutic vulnerability in cancer

Y. Bei, L. Brame, M. Kirchner, R. Fritsche, S. Kunz, A. Bhattacharya, J. Koeppke, J. Proba, N. Wittstruck, O. Sidorova, R. Chamorro, H. Dorado Garcia, L. Brueckner, R. Xu, M. Giurgiu, , A. Henssen

The paper identifies DDX1 as a passenger gene co-amplified with MYCN in cancer, showing that its aberrant expression creates a therapeutic vulnerability through mTORC1 dependency.

bioRxiv · Sep 8, 2022 · PreprintCancer Biology

Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma

K. Helmsauer, M. Valieva, S. Ali, R. Chamorro Gonzalez, R. Schoepflin, C. Roeefzaad, Y. Bei, H. Dorado Garcia, E. Rodriguez-Fos, M. Puiggros, V. Heinrich, M. Robson, K. Kasack, K. Haase, L. P. Kuschel, , R. P. Koche

The paper identifies two distinct MYCN amplicon structures in neuroblastoma, showing how enhancer hijacking compensates for loss of local regulatory elements.

bioRxiv · Dec 20, 2019Cancer Biology

Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors

A. Henssen, R. Koche, J. Zhuang, E. Jiang, C. Reed, A. Eisenberg, E. Still, I. MacArthur, E. Rodriguez-Fos, S. Gonzalez, M. Puiggros, A. Blackford, C. Mason, E. De Stanchina, M. Gonen, , A. Kentsis

This study identifies PGBD5 as an oncogenic DNA transposase in rhabdoid tumors, causing site-specific genomic rearrangements through PSS sequences and end-joining repair.

bioRxiv · Feb 23, 2017Cancer Biology