Author

R. Sean Manning

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Aakanksha SinghviiD· 2 shared Alexandra A. Kravchuk· 1 shared Elgene J. A. QuitevisiD· 1 shared Liza J. SeversiD· 1 shared Manu N. SettyiD· 1 shared Maria D. PuriceiD· 1 shared Natalie Tran· 1 shared Pralaksha GurungiD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Aakanksha SinghviORCID

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2 papers

Recent·Most cited

Molecular heterogeneity of C. elegans glia across sexes

Maria D. Purice, Elgene J. A. Quitevis, R. Sean Manning, Liza J. Severs, Natalie Tran, Violet Sorrentino, Manu N. Setty, Aakanksha Singhvi

The paper identifies molecular subcategories of C. elegans glia across sexes using single nuclear RNA-seq and machine learning, revealing sex-specific heterogeneity and alternative neuromodulator processing mechanisms.

bioRxiv · Mar 21, 2023 · PreprintNeuroscience

Neuron cilia constrain glial regulators to microdomains around distal neurons

Sneha Ray, Pralaksha Gurung, R. Sean Manning, Alexandra A. Kravchuk, Aakanksha Singhvi

The paper shows glia compartmentalize regulatory cues into microdomains around specific neurons, with KCC-3 localization dependent on neuron cilia and aging.

bioRxiv · Mar 18, 2023 · PreprintNeuroscience