Transformation of primary murine peritoneal mast cells by constitutive KIT activation as a result of lost Cdkn2a/Arf expression
S. Capellmann, R. Sonntag, H. Schueler, S. K. Meurer, L. Gan, M. Kauffmann, K. Horn, H. Koenigs-Werner, R. Weiskirchen, C. Liedtke, M. Huber
The paper describes the generation of a transformed murine mast cell line, PMC-306, and identifies the loss of Cdkn2a/Arf as the cause of its immortalization.
bioRxiv · Jan 24, 2023 · PreprintImmunology