L. Gan

A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide

This study shows that AOAH inactivates intestinal LPS, reducing MASLD by preventing hepatic lipid accumulation and altering lipid metabolism gene expression.

CREB REGULATES FOXP3+ST-2+ TREGS WITH ENHANCED IL-10 PRODUCTION

This study shows that CREB knockout in Foxp3+ Tregs increases IL-10 and ST-2 expression, enhancing their suppressive function and preventing gut inflammation.

Early life high fructose exposure disrupts microglia function and impedes neurodevelopment

This study shows that early life high fructose exposure impairs microglia function and neurodevelopment, with GLUT5 deletion reversing these effects.

Nanoscale analysis of human G1 and metaphase chromatin in situ

This study uses in situ electron cryotomography to analyze chromatin structure in G1 and metaphase human cells, revealing distinct nucleosome arrangements and absence of higher-order structures in certain states.

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

The paper uses CRISPR screens in iPSC-derived neurons to identify factors controlling tau aggregation, finding new pathways and potential therapeutic targets for tauopathies.

Transformation of primary murine peritoneal mast cells by constitutive KIT activation as a result of lost Cdkn2a/Arf expression

The paper describes the generation of a transformed murine mast cell line, PMC-306, and identifies the loss of Cdkn2a/Arf as the cause of its immortalization.

Meiotic budding yeast assemble bundled triple helices but not ladders

The paper uses cryo-ET to analyze budding yeast meiosis and finds meiotic triple helices (MTHs) instead of expected synaptonemal complexes.

DIA-based Proteomics Identifies IDH2 as a Targetable Regulator of Acquired Drug Resistance in Chronic Myeloid Leukemia

This study identifies IDH2 as a targetable regulator of drug resistance in CML by analyzing proteomic changes in resistant K562 cells.

Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ

This study uses cryo-ET to show that most nucleosomes in yeast cells are non-canonical, challenging previous assumptions about their structure.

An uncanonical transcription factor-DREB2B regulates seed vigor negatively through ABA pathway

This study identifies DREB2B as a negative regulator of seed vigor through the ABA pathway in Arabidopsis and cotton, interacting with RCD1 and synergizing with ABI3.

Macromolecular and cytological changes in fission yeast G0 nuclei

The paper compares transcription, histone acetylation, and macromolecular packing in proliferating and quiescent G0 fission yeast nuclei using cytological and biochemical methods.

A collection of yeast cellular electron cryotomography data

The paper shares over 1,000 cryo-ET raw datasets of yeast cells to enable structural and 3-D biological insights.

The in situ structures of mono-, di-, and tri-nucleosomes in human heterochromatin

This study uses cryo-ET to determine the in situ structures of mono-, di-, and tri-nucleosomes in human heterochromatin, revealing irregular paths and conformational variability.

A multi-scale model of the yeast chromosome-segregation system

The paper studies the yeast chromosome-segregation system using electron cryotomography and perturbations, revealing the structure and dynamics of kinetochore-microtubule interactions.

Cryo-ET reveals nucleosome reorganization in condensed mitotic chromosomes in vivo

The paper uses cryo-ET to study nucleosome organization in fission yeast mitotic chromosomes, revealing cluster and megacomplex structures and explaining gene expression patterns during mitosis.

Natural Chromatin Is Heterogeneous And Self Associates In Vitro

This study investigates the structure of natural chromatin in vitro using cryo-ET, showing it forms compact masses with rare 30-nm fibers and is sensitive to divalent cations and histone modifications.