Author

R. Sreenivasan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. Drennan· 1 shared C. J. Layton· 1 shared C. K. Cimperman· 1 shared C. McNerney· 1 shared D. Herschlag· 1 shared D. Plaskon· 1 shared H.-C. Wang· 1 shared I. A. Shkel· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. Drennan

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2 papers

Recent·Most cited

Fluorescence-Detected Conformational Changes in Duplex DNA in Open Complex Formation by E. coli RNA Polymerase: Upstream Wrapping and Downstream Bending Precede Clamp Opening and Insertion of the Downstream Duplex

R. Sreenivasan, I. A. Shkel, M. Chhabra, A. Drennan, S. Heitkamp, H.-C. Wang, M. A. Sridevi, D. Plaskon, C. McNerney, K. Callies, C. K. Cimperman, M. T. Record

This study uses FRET and PIFE to analyze DNA conformational changes during E. coli RNA polymerase open complex formation, revealing upstream wrapping and downstream bending before clamp opening.

bioRxiv · Feb 4, 2020Biochemistry

A quantitative and predictive model for RNA binding by human Pumilio proteins

I. Jarmoskaite, S. K. Denny, P. P. Vaidyanathan, W. R. Becker, J. O. L. Andreasson, C. J. Layton, K. Kappel, V. Shivashankar, R. Sreenivasan, R. Das, W. J. Greenleaf, D. Herschlag

The paper develops a predictive model for RNA binding by human PUM1 and PUM2 using RNA-MaP data, showing residue flipping and positional coupling, and validates it against in vivo crosslinking data.

bioRxiv · Aug 29, 2018Biochemistry