Author

M. T. Record

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1

Frequent Co-Authors

I. A. Shkel· 2 shared A. Drennan· 1 shared A. G. Kozlov· 1 shared A. R. Manzano· 1 shared B. Nguyen· 1 shared C. K. Cimperman· 1 shared C. McNerney· 1 shared D. Jensen· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

I. A. Shkel

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3 papers

Recent·Most cited

High-throughput, fluorescent-aptamer-based measurements of steady-state transcription rates for Mycobacterium tuberculosis RNA polymerase

D. Jensen, A. R. Manzano, E. J. Tomko, M. Rector, M. T. Record, E. A. Galburt

This paper introduces a fluorescent-aptamer-based method to measure steady-state transcription rates of Mycobacterium tuberculosis RNA polymerase with high throughput and precision.

bioRxiv · Mar 13, 2023 · PreprintBiochemistry

How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein

A. G. Kozlov, X. Cheng, H. Zhang, M. K. Shinn, E. Weiland, B. Nguyen, I. A. Shkel, E. Zytkiewicz, I. J. Finkelstein, M. T. Record, T. M. Lohman

This study shows that potassium glutamate promotes liquid-liquid phase separation and non-nearest-neighbor cooperativity of E. coli SSB protein through amide group interactions, while KCl inhibits these processes.

bioRxiv · Jan 17, 2022Biochemistry

Fluorescence-Detected Conformational Changes in Duplex DNA in Open Complex Formation by E. coli RNA Polymerase: Upstream Wrapping and Downstream Bending Precede Clamp Opening and Insertion of the Downstream Duplex

R. Sreenivasan, I. A. Shkel, M. Chhabra, A. Drennan, S. Heitkamp, H.-C. Wang, M. A. Sridevi, D. Plaskon, C. McNerney, K. Callies, C. K. Cimperman, M. T. Record

This study uses FRET and PIFE to analyze DNA conformational changes during E. coli RNA polymerase open complex formation, revealing upstream wrapping and downstream bending before clamp opening.

bioRxiv · Feb 4, 2020Biochemistry