Author

M. Chhabra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. A. Khromykh· 2 shared D. Watterson· 2 shared N. Modhiran· 2 shared V. Ferro· 2 shared A. A. Amarilla· 1 shared A. Amarilla· 1 shared A. Drennan· 1 shared A. Suhrbier· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

A. A. Khromykh

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

SARS-CoV-2 triggers complement activation through interactions with heparan sulfate

M. W. Lo, A. A. Amarilla, J. D. Lee, E. A. Albornoz, N. Modhiran, R. J. Clark, V. Ferro, M. Chhabra, A. A. Khromykh, D. Watterson, T. M. Woodruff

This study shows SARS-CoV-2 activates the complement system via heparan sulfate interactions, leading to C5a production and delayed granulocyte/monocyte activation.

bioRxiv · Jan 11, 2022Immunology

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction

S. E. Guimond, C. J. Mycroft-West, N. S. Gandhi, J. A. Tree, T. T. Le, C. M. Spalluto, M. V. Humbert, K. R. Buttigieg, N. Coombes, M. J. Elmore, K. Nystrom, J. Said, Y. X. Setoh, A. Amarilla, N. Modhiran, , J. E. Turnbull

This paper shows that pixatimod inhibits SARS-CoV-2 by disrupting the Spike-ACE2 interaction, demonstrating its potential as an anti-COVID-19 therapeutic.

bioRxiv · Jun 24, 2020Microbiology

Fluorescence-Detected Conformational Changes in Duplex DNA in Open Complex Formation by E. coli RNA Polymerase: Upstream Wrapping and Downstream Bending Precede Clamp Opening and Insertion of the Downstream Duplex

R. Sreenivasan, I. A. Shkel, M. Chhabra, A. Drennan, S. Heitkamp, H.-C. Wang, M. A. Sridevi, D. Plaskon, C. McNerney, K. Callies, C. K. Cimperman, M. T. Record

This study uses FRET and PIFE to analyze DNA conformational changes during E. coli RNA polymerase open complex formation, revealing upstream wrapping and downstream bending before clamp opening.

bioRxiv · Feb 4, 2020Biochemistry