Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates
J. R. Giles, S. F. Ngiow, S. Manne, A. E. Baxter, O. Khan, P. Wang, R. Staupe, M. S. Abdel-Hakeem, H. Huang, D. Mathew, M. M. Painter, J. E. Wu, Y. J. Huang, R. Goel, E. J. Wherry
This study maps transcriptional and epigenetic changes in CD8 T cell differentiation using scRNA-seq and scATAC-seq, revealing shared biological circuits across effector, memory, and exhausted cell fates.
bioRxiv · Mar 27, 2022 · PreprintImmunology